Synthesis, antifungal activity, and QSAR studies of 1,6-dihydropyrimidine derivatives

Synthesis and antifungal activity of carabrone derivatives.

Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents ...

Oleoylsalicylate Derivatives: Synthesis and Antifungal Activity

Three new “hybrid” molecules containing the skeleton of oleic acid and salicylic acid were synthesised. A qualitative study of the chemical stability of two of them and a preliminary evaluation of their biological activity in vivo and in vitro were performed against a series of important plant pathogens.

synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives

Synthesis, Structure-Activity Relationships (SAR) and in Silico Studies of Coumarin Derivatives with Antifungal Activity

The increased incidence of opportunistic fungal infections, associated with greater resistance to the antifungal drugs currently in use has highlighted the need for new solutions. In this study twenty four coumarin derivatives were screened in vitro for antifungal activity against strains of Aspergillus. Some of the compounds exhibited significant antifungal activity with MICs values ranging be...

Synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives

In recent years, the use of antifungal drugs in human medicine has increased, especially with the advent of AIDS epidemic. Efforts have focused on the development of new, less toxic and more efficacious antifungal drugs with novel mechanism of action. The purpose of this study was to synthesize of some new benzimidazole, benzotriazole and aminothiazole derivatives and to evaluate their activity...